On the greatly-exaggerated demise of the insulin-hypothesis

Last week, I tweeted a New England Journal of Medicine image challenge, part of the journal’s continuing education program for physicians. I suggested that it might be a source of comfort to those who were worried about the insulin hypothesis as a viable hypothesis to explain obesity and excess fat accumulation. Although I linked to the NEJM page and the link worked for me, I gather some who tried to click on it were presented with other image challenges and were wondering, for instance, why I cared if they could diagnose a pneumothorax when they saw one. So here’s the image challenge I had in mind, and the correct response is below. The relevance should be reasonably obvious.

Download NEJM Image Challenge (PDF)